In film, Moss had supporting roles in Girl, Interrupted (1999), Get Him to the Greek (2010), and Us (2019) and starring roles in The One I Love (2014), The Square (2017), and The Invisible Man (2020).

For producing and starring as June Osborne in the Hulu dystopian drama series The Handmaid's Tale (2017–present), Moss won the Primetime Emmy Award for Outstanding Lead Actress in a Drama Series and Outstanding Drama Series, among other accolades. She earned wider recognition for playing Peggy Olson, a secretary-turned-copywriter, in the AMC period drama series Mad Men (2007–2015), and subsequently won the Critics' Choice Television Award for Best Actress in a Movie/Miniseries and the Golden Globe Award for Best Actress – Miniseries or Television Film for portraying Detective Robin Griffin in the BBC miniseries Top of the Lake (2013). Moss began acting in the early 1990s and first gained recognition for playing Zoey Bartlet, the youngest daughter of President Josiah Bartlet, in the NBC political drama series The West Wing (1999–2006). Dubbed the 'Queen of Peak TV' by Vulture, she has received numerous accolades, including three Critics' Choice Awards, two Golden Globe Awards, two Primetime Emmy Awards and two Screen Actors Guild Awards. Elisabeth Singleton Moss (born July 24, 1982) is an American actor, producer and director.